Raw data are available on GEO, accession number GSE182685. The computational analysis is described on https://github.com/vangalenlab (including links to maegatk and mitochondrial variant annotation resources) and https://github.com/petervangalen/MAESTER-2021 (including downstream analysis and figure generation). To faciliate execution of these scripts, processed data files are available through the links listed below.
Data description
Filename
MAESTER mitochondrial variant data: Seq-Well cell line mix (all reads)
MAESTER mitochondrial variant data: Seq-Well cell line mix (RNA-seq reads only)
MAESTER mitochondrial variant data: 10x cell line mix (all reads)
MAESTER mitochondrial variant data: 10x cell line mix (RNA-seq reads only)
MAESTER mitochondrial variant data: 10x cell line mix (filtered)
MAESTER mitochondrial variant data: Seq-Well Glioblastoma region A
MAESTER mitochondrial variant data: Seq-Well Glioblastoma region C
MAESTER mitochondrial variant data: Seq-Well Glioblastoma PBMCs
MAESTER mitochondrial variant data: 10x clonal hematopoiesis sample (all reads)
MAESTER mitochondrial variant data: 10x clonal hematopoiesis sample (RNA-seq reads only)
MAESTER mitochondrial variant data: 10x multiome analysis
scRNA-seq expression data: Seq-Well cell line mix
scRNA-seq expression data: 10x cell line mix
scRNA-seq expression data: 10x clonal hematopoiesis sample
Seurat object: Seq-Well cell line mix
Seurat object: 10x cell line mixing
Seurat object: 10x clonal hematopoiesis sample (unfiltered)
Seurat object: 10x clonal hematopoiesis sample (filtered)
Seurat object: 10x clonal hematopoiesis sample (additional metadata)